Season 2, Episode 1 -Sperm and male fertility
Updated: Apr 5, 2022
Watch the episode on youtube here.
All the important links, repro news and guest bios from this month's episode
Professor Moira O'Bryan
Prof O’Bryan is a reproductive biologist with expertise in the area of fundamental mechanisms required to produce fertile sperm, the causes of male infertility and the role of sperm structure-function as a driver of evolution. Areas of particular emphasis of her laboratory include the mechanisms of sperm head shaping and cilia/flagellar development and function, genetic causes of human infertility, the importance of epigenetic regulation in male fertility and transgenerational health, and the connection between male fertility and overall health – a concept often referred to as ‘the canary in the coalmine hypothesis’. To achieve these aims, her laboratory uses a range of animal and cell models, high end imaging technologies and suites of biochemical and cell biology approaches.
Prof. O’Bryan is the Dean of Science at the University of Melbourne. She currently sits on the editorial boards of Molecular Human Reproduction, Andrology and PLOS Genetics. She, along with Prof. Rob McLachlan from the Hudson Institute of Medical Research, run the Monash Male Infertility Repository. She is also a past President of the Society of Reproductive Biology and has received numerous awards for her contributions to the field of reproductive biology.
Early Career Researcher Spotlight
Dr Natalie Trigg
Natalie received her Bachelor of Biotechnology (Honours) (2016) and PhD (2021) from the University of Newcastle, Australia. During her PhD Natalie investigated the impact of paternal environmental exposure on the sperm small RNA profile. Specifically, her research investigated the impact of exposure to the xenobiotic, acrylamide during epididymal transit, on the sperm small RNA profile and how exposure mediates changes in the sperm small RNA profile and the consequences to embryo gene expression. Now as a postdoctoral research fellow at the University of Pennsylvania and Children’s Hospital of Philadelphia Natalie’s research focus lies in uncovering the cellular functions of epididymal acquired sperm small RNAs after fertilization.
If you want to learn more about this episode's fun fact, check out the article below:
Sperm structure and motility in the eusocial naked mole-rat, Heterocephalus glaber: a case of degenerative orthogenesis in the absence of sperm competition?
Upcoming conferences and abstract deadlines
47th American Society of Andrology (ASA) Annual Conference
7th - 10th May 2022, La Jolla, California
Abstracts due 3rd April
11th Asia Pacific Initiative on Reproduction (ASPIRE) 2022
28th April - 1st May 2022 (virtual only)
Abstract submissions are closed, registration open
Reproductive Aging Conference
5th - 9th June 2022, Palm Springs, California
Abstracts due 25th April
North American Testis Workshop
4th-7th May 2022 (preceding ASA)
Introduction to Equine Reproduction Workshop
2nd - 3rd April 2022, Oakey, QLD
Upcoming awards and grants
SRF Marshall Medal 2022
Nominations due by 30th April 2022
SRF Distinguished Scientist Anne McLaren Award
Nominations due by 30th April 2022
Paper of the month
Viable offspring derived from single unfertilized mammalian oocytes
Can't get enough? Check out these bonus items:
The International Male Infertility Genomics Consortium
A recent(ish) review on genetic causes of male infertility, and another review on the techniques currently being developed to screen for genetic infertility factors
Episode sponsored by